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However, incidence of clinical worsening did not differ with sildenafil therapy. Based on the results of SUPER, the FDA-recommended dose for treatment of PAH is 20 mg three-times daily.
Methods: This randomised, double blind (DB), placebo controlled, flexible dose study with an open label extension (OLE) assessed efficacy, QoL, and safety of sildenafil citrate in men with MS and ED.
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