The New York Giants snapped a franchise-record 10-game losing streak and ended the Indianapolis Colts’ slim playoff hopes Sunday as Drew Lock threw four touchdown passes and ran for another in a 45-33 victory.

Anthony Richardson has been ruled out vs. the New York Giants, the Colts announced Saturday. Joe Flacco will start at quarterback. The Colts second-year quarterback was listed as questionable on the injury report after missing the entire week of practice due to foot and back injuries this week.

Indianapolis Colts linebacker E.J. Speed (knee) and left guard Quenton Nelson (ankle) are active for Sunday's Week 17 contest against the Jacksonville Jaguars. Both players had been listed as questionable.

Tight end Mo Alie-Cox (toe), linebacker Jaylon Carlies (shoulder), linebacker E.J. Speed (knee), guard Quenton Nelson (ankle), and second-year cornerback JuJu Brents (knee) were all questionable for Sunday's bout. Their statuses will be ones to monitor over the weekend.

The Indianapolis Colts host the Tennessee Titans in NFL Week 16 action. Here are the key players who won't play because of injury.

The Indianapolis Colts visit the New York Giants in NFL Week 17 action. Both teams will be watching injuries to key players.

Pierce suffered a concussion against the Broncos last week and head coach Shane Steichen said on Friday that he has been ruled out for this weekend. Pierce leads the team with 645 receiving yards, so his absence will be a noticeable one for the offense.

Indianapolis Colts receiver Alec Pierce will miss Sunday's game against the visiting Tennessee Titans due to a concussion. Starting linebacker E.J. Speed (knee) also will miss the AFC South contest.

Aug 28, 2020; Indianapolis, Indiana, USA; Indianapolis Colts linebacker E.J. Speed (45) catches a ball during colts training camp at the Farm Bureau Football Complex. Mandatory Credit: Marc Lebryk ...

The Indianapolis Colts host the Tennessee Titans in NFL Week 16 action as the Colts try to remain in the AFC playoff race. Wide receiver Alec Pierce (concussion) and linebacker E.J. Speed ...

The New York Giants, who controlled their own destiny to secure the No. 1 pick, put up 45 points to upset the Indianapolis Colts. And if that wasn't enough, the Jacksonville Jaguars took down the Tennessee Titans and the Las Vegas Raiders won their second ...

A Colts season that began with hopes of a playoff berth and a division title will end the same way as so many Indianapolis seasons over the past decade. Out of the playoffs, lamenting a missed opportunity against an overmatched opponent.