Gut-Brain Connection. People who have CD83+ microglia in their brains also have HCMV (top left) and IgG4 (top right) in their ...

Notably, this coupling crumbles with age in mice. Restoring it not only bolstered neuronal energy reserves, but also strengthened synaptic signaling and counteracted memory loss in old animals.

The easiest way to track down "when" in a chronic disorder like AD is with the causal quartet, those carrying disease-causing mutations in APP, PSEN1, PSEN2 and SORL1, and, as you expand, including ...

This letter was prompted by your recent perspective paper and the responses it provoked in an Alzforum discussion. Generally, my comments are offered with the intellectual humility required when ...

Poor physical health, difficulty with daily routines, and low scores on tests of thinking, memory, and information processing most strongly predict dementia later in life, according to a new report by ...

Both presenilin-1 or the less-studied presenlin-2 can act as the catalytic subunit of γ-secretase, the enzyme responsible for churning out Aβ peptides. A new study, published November 29 in Nature ...

Some people’s brains age faster than average, some slower. Scientists quantify this “brain age gap” by subtracting a person’s chronological age from their brain’s biological age. Because aging brains ...

Columbia University Class of 2017, BA in Neuroscience with Concentration in Chemistry University of Pennsylvania, M.D.-Ph.D. Student ...

Many genes and proteins have been linked to Alzheimer’s, but which ones directly contribute to disease? This question has been hard to answer. In the December 11 Cell Genomics, scientists led by ...

Why is age the strongest risk factor for Alzheimer’s disease? In the December 10 Science Signaling, scientists led by Ning Bai, Difei Wang, Yu Di, and Liu Cao at China Medical University in Shenyang, ...

Millions of small molecules coursing through our bodies reflect biochemical processes that factor in health and disease. Studies have tied such metabolites in blood and urine to genetic variants. Now, ...