No. 2 pick Jayden Daniels and the Commanders are favored by 3.5 points in the Week 17 NFL odds, over No. 8 pick Michael Penix and the Falcons. The over-under for that game is 46. Before that, however,

The 49ers’ offensive line and running backs are incredibly banged up. That makes life difficult for San Francisco quarterback Brock Purdy. While the Lions are dealing with their own rash of injuries, Jared Goff and Detroit deliver and exact revenge in a game where they have much more at stake.

NFL Week 18 picks, predictions, win probabilities for Chiefs vs Broncos, Vikings vs Lions, Cardinals vs 49ers, Seahawks vs Rams, more games this week.