The 49ers lost defensive tackle Javon Hargrave early with a torn triceps. Middle linebacker Fred Warner has played with an ankle fracture. Running mate Dre Greenlaw didn’t come back until Week 15, and now may be done for the year. Safety Talanoa Hufanga has attempted to rebound from a torn ACL, an ankle sprain and then wrist surgery.

The Los Angeles Rams, Green Bay Packers, Tampa Bay Buccaneers, Seattle Seahawks and Atlanta Falcons are still in the hunt in the playoffs. The Detroit Lions, Philadelphia Eagles and Minnesota Vikings have clinched playoff spots for the this season.

After the San Francisco 49ers blew multiple opportunities and committed a season-high 11 penalties in a loss to the Miami Dolphins, 49ers head coach Kyle Shanahan made his message clear: his team did not deserve the win.

San Francisco 49ers head coach Kyle Shanahan addressed reporters during a Monday conference call, delivering multiple injury updates that could

The San Francisco 49ers need to do something different offensively. Last season they were one of the best outfits in the NFL. This season they’ve sputtered on that side of the ball. Injuries

On Friday this week, head coach Kyle Shanahan was asked about Purdy's harsh self-assessment.

Recent comments from QB Brock Purdy about losing some of the chip on his shoulder has San Francisco 49ers HC Kyle Shanahan confused.

The bad news keeps piling up for the San Francisco 49ers as Kyle Shanahan revealed that a veteran offensive player will be sidelined for the team’s next two games. The San Francisco 49ers are nearing the end of the regular season,

San Francisco's slim postseason hopes are officially over, as Kyle Shanahan addresses the 49ers' elimination following their loss to the Miami Dolphins.

Kyle Shanahan has made it clear that retaining two of the team's defensive stars, Dre Greenlaw & Talanoa Hufanga, is a top priority